Who does what?
As living creatures, we are continually interacting with our surroundings and our immune system is required to distinguish non-harmful entities from dangerous intruders and react accordingly. CD4 T cells are activated by antigen presenting cell (APC) and acquire alternative cell fates to mediate distinct immune responses. Our research suggests that distinct APC subsets are specialized in the initiation of different T cell programs. So, who is doing what, and where? and what are the implications of having the ‘wrong’ cell at the ‘wrong’ place? Using models of gut microbes and mice genetics we will keep on deciphering the unique role of each APC subset in directing specific immune responses.
We aim to pave the way for future treatments targeting specific APC subtypes to redirect immune response and treat immune-related diseases.